John P. Morrow, MD

Board Certifications: 
Clinical Cardiac Electrophysiology, Internal Medicine, Cardiovascular Disease
Profile Headshot

Overview

Areas of Expertise / Conditions Treated

Cardiac Electrophysiology

Academic Appointments

  • Assistant Professor of Medicine at CUMC

Administrative Titles

  • Assistant Professor, Department of Medicine, Division of Cardiology
  • Co-Director of Cardiology Grand Rounds

As a physician-scientist I devote 75% of my time to laboratory research. My work as a clinical cardiologist informs my translational research program. My ultimate goal is to develop novel therapeutics to prevent and treat the cardiac complications of metabolic diseases.The goal of my research is to determine the molecular mechanisms that cause arrhythmias and cardiomyopathy during metabolic stress. My laboratory investigates disease models of chronic metabolic stress (e.g. obesity) and acute metabolic stress (e.g. sepsis), using molecular biology, cellular physiology, and in vivo techniques.

Hospital Affiliations

  • NewYork-Presbyterian/Columbia

Languages

  • Spanish

Gender

  • Male

Location(s)

CUMC/Russ Berrie Medical Science Pavilion
1150 St. Nicholas Avenue
New York, NY 10032
Primary

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Medicare Managed Care
  • NY Signature
  • NYP Employee Plan
  • POS
  • PPO
  • Signature Administrators
  • Student Health

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Emblem/GHI

  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Access (Exchange)
  • EPO
  • Gatekeeper (Exchange)
  • HMO
  • Medicare Managed Care
  • Pathway (Exchange)
  • POS
  • PPO

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Medicare

  • Traditional Medicare (NY)

Multiplan

  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO
  • The Empire Plan (NYSHIP)

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Credentials & Experience

Education & Training

  • Columbia University College of Physicians and Surgeons
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Board Certifications

  • Clinical Cardiac Electrophysiology
  • Internal Medicine
  • Cardiovascular Disease

Honors & Awards

2011    Teacher of the Year, Cardiology Training Program, CUMC

2009    Katz Prize in Cardiovascular Research, CUMC

2005    Hamilton Southworth Research Award for Fellows, CUMC

Research

The goal of my research is to determine the molecular mechanisms that cause arrhythmias and cardiomyopathy during metabolic stress. My laboratory investigates disease models of chronic metabolic stress (e.g. obesity), using molecular biology, cellular physiology, and in vivo techniques. Little is known about the contribution of metabolic abnormalities to the pathophysiology of heart failure, arrhythmias, and hypertrophy. I have extensive experience with standard molecular biology techniques, cell culture, immunohistochemistry, cardiomyocyte isolation, patch clamp, and small animal survival surgery. 

I have long-term collaborations with other researchers at my own institution and at other universities. I am a member of the NY Obesity Nutrition Research Center (NYONR) an NIH funded center that provides infrastructure for studies related to metabolism, nutrition and obesity. I am also dedicated to educating and training the next generation of cardiovascular researchers, both students and post-docs. Several students have completed master’s theses in my lab. I have also served on the thesis committee of PhD students.

As a physician-scientist I devote 75% of my time to laboratory research. My work as a clinical cardiologist informs my translational research program. My ultimate goal is to develop novel therapeutics to prevent and treat the cardiac complications of metabolic diseases.

Research Interests

  • Ion channel regulation
  • Translational research in cardiac electrophysiology
  • obesity/metabolic syndrome
  • cardiac metabolism

Grants

MOLECULAR MECHANISMS OF ARRHYTHMIA CAUSED BY HIGH-FAT DIET (Federal Gov)

Jan 15 2018 - Nov 30 2022

NEW YORK OBESITY RESEARCH CENTER (Federal Gov)

Dec 1 1996 - Mar 31 2021

MECHANISMS OF ARRHYTHMIA INDUCED BY HIGH-FAT DIET (Private)

Jul 1 2016 - Jun 30 2018

MECHANISMS OF VENTRICULAR TACHYCARDIA IN LIPOTOXIC CARDIOMYOPATHY (Federal Gov)

Apr 12 2011 - Mar 31 2016

CAREER TRACKS TOWARDS EXCELLENCE (Private)

Jul 1 1993 - Jun 30 2012

Selected Publications

1. Leroy C. Joseph, Prakash Subramanyam, Christopher Radlicz, Chad M. Trent, Vivek Iyer, Henry M. Colecraft, John P. Morrow*. Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia. Heart Rhythm, 2016, in press.
2. Leroy C. Joseph, Emanuele Barca, Prakash Subramanyam, Michael Komrowski, Utpal Pajvani, Henry M. Colecraft, Michio Hirano, John P. Morrow*. Inhibition of NAPDH oxidase 2 (NOX2) prevents oxidative stress and mitochondrial abnormalities caused by saturated fat in cardiomyocytes. PLOS ONE, 2016, DOI: 10.1371/journal.pone.0145750
3. Elaine Wan, Jeffrey Abrams, Richard L. Weinberg, Alex N. Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John P. Morrow, Hasan Garan, and Steven O. Marx. Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. Journal of Clinical Investigation, 2015, doi:10.1172
4. Shuang Zhang, Xin-Yi Yeap, Lubov Grigoryeva, Shirley Dehn, Matthew DeBerge, Michael Tye, Emily Rostlund, Dorien Schrijvers, Zheng Jenny Zhang,  Ronen Sumagin, Warren G. Tourtellotte, Daneil Lee, Jon Lomasney, John Morrow, Edward B. Thorp. Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis. Journal of Molecular and Cellular Cardiology, 2015, 87: 171-179
5. Ji-Yeon Shin, Caroline Le Dour, Fusako Sera, Shinichi Iwata, Shunichi Homma, Leroy C. Joseph, John P. Morrow, William T. Dauer, Howard J. Worman. Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice. Nucleus, 2014, 5(3):260-459
6. Haiyan Huang, Leroy C. Joseph, Michael Gurin, Edward Thorp, John P. Morrow*. Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription. Journal of Molecular and Cellular Cardiology, 2014, 75: 58–63
7. Lin Yang, Alexander N. Katchman, Tahmina Samad, John P. Morrow, Richard Weinberg and Steven O. Marx. Beta-Adrenergic Regulation of the L-type Ca2+ Channel Does Not Require Phosphorylation of a1C Ser1700. Circulation Research, 2013, 113:871-880.
8. Elaine Wan, Xin Yi Yeap, Shirley Dehn, Rachael Terry, Margaret Novak, Shuang Zhang, Shinichi Iwata, Xiaoqiang Han, Shunichi Homma, Konstantinos Drosatos, Jon Lomasney, David M. Engman, Stephen D. Miller, Douglas E. Vaughan, John P. Morrow, Raj Kishore, and Edward B. Thorp. Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through MER Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction. Circulation Research, 2013, 113:1004-1012.
9. Haiyan Huang, Vaibhav Amin, Michael Gurin, Elaine Wan, Edward Thorp, Shunichi Homma, John P. Morrow*. Diet-induced obesity causes long QT and reduces transcription of voltage-gated potassium channels. Journal of Molecular and Cellular Cardiology, 2013, 59: 151–158
10. Arthur R Garan, Kerry Morrison, Laurie Letarte, Jesus Vazquez, Drew Dano, Paolo Colombo, Melana Yuzefpolskaya, Rosie Te-Frey, Hiroo Takayama, Yoshifumi Naka, John Morrow, Hasan Garan, Ulrich P Jorde, Nir Uriel. Ventricular Arrhythmias in Patients Following Continuous Flow Left Ventricular Assist Device Implantation. JACC, 2013, 61(25): 2542-50
11. Jason C. Choi, Antoine Muchir, Wei Wu, Shinichi Iwata, Shunichi Homma, John Morrow,  Howard J. Worman. Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation. Science Translational Medicine, 2012, 4: 144ra102
12. Antoine Muchir, Wei Wu, Jason C. Choi, Shinichi Iwata, John Morrow, Shunichi Homma and Howard J. Worman. Abnormal p38a mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation. Human Molecular Genetics, 2012, 1–9
13. Lin Yang, Alexander Katchman, John P. Morrow, Darshan Doshi, and Steven O. Marx. Cardiac L-Type Calcium Channel Associates with Gamma Subunits. FASEB Journal, 2011, 25(3):928-36
14. John P. Morrow, Alex Katchman, Ni-Huiping Son, Chad M. Trent, Raffay Khan, Takayuki Shiomi, Haiyan Huang, Vaibhav Amin, Joshua M. Lader, Carolina Vasquez, Gregory E. Morley, Jeanine D'Armiento, Shunichi Homma, Ira J. Goldberg, Steven O. Marx.  Mice with cardiac overexpression of PPARgamma have impaired repolarization and spontaneous fatal ventricular arrhythmias. Circulation, 2011, 124:2812-2821
15. Lin Yang, Darshan Doshi, John Morrow, Alexander Katchman, Xiang Chen, Steven Marx. PKC isoforms differentially phosphorylate Cav1.2 alpha1c. Biochemistry, 2009, vol 48(28): 6674-6683
16. John P. Morrow, Sergey I. Zakharov, Guoxia Liu, Lin Yang, Andrea Sok, Steven O. Marx. Defining the BK channel domains required for Beta-1 subunit modulation. Proceedings of the National Academy of Science, 2006, vol 103: 5096-5101
17. Lin Yang, Guoxia Liu, Sergey I. Zakharov, John P. Morrow, Vitali O. Rybin, Susan F. Steinberg, and Steven O. Marx. Ser1928 Is a Common Site for Cav1.2 Phosphorylation by Protein Kinase C Isoforms. Journal of Biological Chemistry, 2005, vol 280: 207 – 214
18. Sergey I. Zakharov, John P. Morrow, Guoxia Liu, Lin Yang, and Steven O. Marx. Activation of the BK (SLO1) Potassium Channel by Mallotoxin. Journal of Biological Chemistry, 2005, vol 280: 30882 – 3088
19. Mintoo Patel, John Morrow, Frederick R. Maxfield, Dudley K. Strickland, Steven Greenberg, and Ira Tabas. The cytoplasmic domain of the low density lipoprotein (LDL) receptor-related protein, but not that of the LDL receptor, triggers phagocytosis. Journal of Biological Chemistry, 2003, vol 278: 44799-44807
20. Haifeng Xue, David O’Neill, John Morrow, and Arthur Bank. A novel mouse gene, Hem T, encoding an hematopoietic cell-specific transcript. Gene, 1999, vol 231: 49-58